Yongmin Cho

Postdoctral Fellow
Department of Systems Biology
Harvard Medical School

EDUCATION

  • Georgia Institute of Technology, Atlanta, GA, USA (2012 - 2017)
    Ph.D. in School of Chemical & Biomolecular Engineering (Advisor: Dr. Hang Lu)
  • Seoul National University, Seoul, South Korea (2005 - 2012)
    B.S. in Department of Chemical and Biological Engineering
    Discontinued Attendance: 2-year mandatory military service in South Korea (2007 – 2009)

POSITIONS AND EMPLOYMENT

  • Postdoctoral Fellow, Department of Systems Biology (2018 – Present)
    Harvard Medical School (Advisor: Dr. Marc W. Kirschner) Kirschner Lab
  • Postdoctoral Fellow, School of Chemical and Biomolecular Engineering (2017 – 2018)
    Georgia Institute of Technology (Advisor: Dr. Hang Lu) Lu Lab
  • Trader, GS Caltex (Petroleum refining company), South Korea (2011 – 2012)

TEACHING EXPERIENCE

  • Instructor, Microfluidic workshop, Georgia Institute of Technology, Atlanta, Georgia 2016
  • Teaching assistant, Transport Phenomena Ι, Georgia Institute of Technology, Atlanta, Georgia 2015 Summer
  • Teaching assistant, Biodesign Lab, Georgia Institute of Technology, Atlanta, Georgia 2014 Spring
  • Teaching assistant, Transport Phenomena ΙΙ, Georgia Institute of Technology, Atlanta, Georgia 2013 Fall
  • Undergraduate Teaching assistant, Engineering Mathematics, Seoul National University, South Korea 2011 Fall
  • Undergraduate Teaching assistant, Chemistry, Seoul National University, South Korea 2009 Fall
  • Undergraduate Teaching assistant, Calculus, Seoul National University, South Korea 2009 Fall

RESEARCH EXPERIENCE

  • Postdoctoral fellow with Dr. Marc W. Kirschner – Harvard Medical School
    • Develop novel technologies (an image-based single-cell sorter for single-cell transcriptomics and an electrophoresis-based rapid multiplexed immunostaining platform) for the characterization of senescent cells in vivo
    • Develop new automated phenotyping platform and analysis pipeline using video tracking and machine learning to discover anti-aging drugs with Daphnia magna (called “water flea”)
    • Study the mechanisms of aging processes from phenotype to genotype with Daphnia magna using Systems Biology approach (single-cell RNA-seq, proteomics, behavior phenotyping, and deep learning)
  • Postdoctoral fellow with Dr. Hang Lu – Georgia Institute of Technology
    • Develop and apply microfluidic sensory-stimulation platforms to understanding multimodal sensory integration in C. elegans nervous system from a single neuron to whole-brain level
  • Ph.D. Research with Dr. Hang Lu – Georgia Institute of Technology
    • Develop new platform for high-throughput controlled mechanical stimulation and functional neuroimaging in C. elegans from larvae to adults worms
    • Develop an automated high-throughput microfluidic platform and an analysis tool for the assessment of health and longevity of C. elegans
  • Research Assistant with Dr. Byung-Soo Kim – Seoul National University
    • Conduct research comparing heparin-conjugated fibrin and a collagen sponge as a BMP-2 delivery system for bone regeneration
    • Conduct research on spatio-temporally concerting gold nanoparticle conjugates for synergistic cancer therapy
  • Field Applications of Engineering Knowledge Program – LG Chemical Research Park, Daejeon, Korea
    • Conduct a project on Pressure Sensitive Adhesives (PSA)
  • Undergraduate Researcher with Dr. Kookheon Char – Seoul National University, Seoul, South Korea
    • Synthesize CdSe quantum dots and designed a new hetero-junction structure concept by cross-linking methods through a liquid colloidal method

INDUSTRY EXPERIENCE

  • Trader – GS Caltex, Seoul, South Korea (2011 - 2012)
    • Analyze and monitor Asia Petrochemical product markets (BTX products – Benzene, Toluene, Xylene)
  • Field Applications of Engineering Knowledge Program – LG Chemical Research Park, Daejeon, Korea (June 2010)
    • Conduct a project on Pressure Sensitive Adhesives (PSA)

AWARDS/FELLOWSHIPS

  • UKC 2022 Fellow, Korea-American Scientist and Engineering Association (2022)
  • SEED Outstanding Presentation Award, Korea-American Scientist and Engineering Association (2022)
  • KASBP Fellowship Award, Korean American Society in Biotech and Pharmaceuticals (2022)
  • CBMS Student/Young Researcher Grant, MicroTAS International Conference (2015)
  • Best Student Research Paper Awards, Seoul National University (2011)
  • National Scholarship For Science and Engineering, Korea Student Aid Foundation (2005 – 2011)
    • Covered the entire 4-year university tuitions

PROFESSIONAL SERVICE

  • Serve as a Journal reviewer at Lab on a chip, Environmental Research, Journal of Industrial and Engineering Chemistry, and STAR Protocols
  • Serve as an editor and a reviewer at Journal of Emerging Investigators

PUBLICATIONS

A. Refereed Journal Publications [* co-first author]

  1. A. V. Shindyapina, Y. Cho, A. Kaya, A. Tyshkovskiy, J. P. Castro, J. Gordevicius, J. R. Poganik, S. Horvath, L. Peshkin, V. N. Gladyshev, “Rapamycin treatment during development extends lifespan and healthspan”. BioRxiv, DOI: 10.1101/2022.02.18.481092 (Under revision in Advanced Science)
  2. C. E. Anderson, M. C. Malek, R. A. Jonas-Closs, Y. Cho, L. Peshkin, M. W. Kirschner, and L. Y. Yampolsky, “Inverse Lansing effect: maternal age and provisioning affecting daughters’ longevity and male offspring production”. (Under revision in American Naturalist)
  3. Y. Cho, R. A. Jonas-Closs, Lev. Y. Yampolsky, M. W. Kirschner, and L. Peshkin, “Intelligent high-throughput intervention testing platform in Daphnia”, Aging Cell, 2022, DOI: 10.1111/acel.13571
  4. C. E. Anderson, M. N. Ekwudo, R. A. Jonas-Closs, Y. Cho, L. M. Peshkin, M. W. Kirschner, and L. Y. Yampolsky, “Lack of Age-related Respiratory Changes in Daphnia”, Biogerontology, 2022, DOI: 10.1007/s10522-021-09947-6
  5. D. W. Choi, Y. J. Roh, S. Kim, H. M. Lee, M. Kim, D. Shin, J. H. Park, Y. Cho, H. H. Park, Y. S. Ok, D. Kang, J. H. Kim, L. Tarrago, N. N. Danial, V. N. Gladyshev, P. K. Min, B. C. Lee, “Development of a novel fluorescent biosensor for dynamic monitoring of metabolic methionine redox status in cells and tissues”, Biosensors and Bioelectronics, 2021, DOI: 10.1016/j.bios.2021.113031
  6. Y. Cho, K. N. Le, M. Zhan*, J. Wan, D. S. Patel, and H. Lu, “An automated platform to monitor long-term behavior and healthspan in Caenorhabditis elegans under precise environmental control”, Communications Biology, 2020, DOI: 10.1038/s42003-020-1013-2
  7. Y. Cho, S. A. Lee, Y. L. Chew, K. Broderick, W. R. Schafer, and H. Lu, “Multimodal Stimulation in a Microfluidic Device Facilitates Studies of Interneurons in Sensory Integration in C. elegans”, Small, 2020, DOI: 10.1002/smll.201905852 (This paper was selected as a cover article)
  8. Y. L. Chew, Y. Tanizawa, Y. Cho, B. Zhao, A. J. Yu, S. Ahn, C. Rankin, Y. J. You, H. Lu, I. Beets, and W. R. Schafer, “An Afferent Neuropeptide System Transmits Mechanosensory Signals Triggering Sensitization and Arousal in C. elegans”, Neuron, 2018, 99 (6), 1233-1246. e6, DOI: 10.1016/j.neuron.2018.08.003
  9. Y. Cho, D. N. Oakland, S. A. Lee, W. R. Schafer, and H. Lu, “On-chip functional neuroimaging to mechanical stimulation in Caenorhabditis elegans larvae for studying functional role of neural circuits” Lab on a chip, 2018, 18, 601-609, DOI: 10.1039/C7LC01201B
  10. T. Rouse, G. Aubry, Y. Cho, M. Zimmer and H. Lu, “A programmable platform for sub-second multichemical dynamic stimulation and neuronal functional imaging in C. elegans” Lab on a chip, 2018, 18, 505-513, DOI: 10.1039/C7LC01116D
  11. Y. Cho, D. A. Porto, H. Hwang, L. J. Grundy, W. R. Schafer, and H. Lu, “Automated and controlled mechanical stimulation and functional imaging in vivo in C. elegans”, Lab on a chip, 2017, 17, 2609-2618, DOI: 10.1039/C7LC00465F
  12. Y. Cho, C. Zhao, and H. Lu. “Trends in High-throughput and Functional Neuroimaging in C. elegans”, WIREs Systems Biology and Medicine, 2017, e01376, DOI: 10.1002/wsbm.1376
  13. D. A. F. de Abreu, A. Caballero, P. Fardel, N. Stroustrup, Z. Chen, K. Lee, W. D. Keyes, Z. M. Nash, I. F. Lo´ pez-Moyado, F. Vaggi, A. Cornils, M. Regenass, A. Neagu, I. Ostojic, C. Liu, Y. Cho, D. Sifoglu, Y. Shen, W. Fontana, H. Lu, A. Csikasz-Nagy, C. T. Murphy, A. Antebi, E. Blanc, J. Apfeld, Y. Zhang, J. Alcedo, Q. Ch’ng, “An Insulin-to-Insulin Regulatory Network Orchestrates Phenotypic Specificity in Development and Physiology”, PLOS Genetics, 2014, 10(3), e1004225, DOI: 10.1371/journal.pgen.1004225
  14. J. Nam, W. La, S. Hwang, Y. S. Ha, N. Park, N. Won, S. Jung, S. H. Bhang, Y. Ma, Y. Cho, M. Jin, J. Han, J. Shin, E. KyungWang, S. G. Kim, S. Cho, J. Yoo, B. Kim, S. Kim, “pH-Responsive Assembly of Gold Nanoparticles and “Spatiotemporally Concerted” Drug Release for Synergistic Cancer Therapy”, ACS Nano, 2013, 7 (4), 3388–3402, DOI: 10.1021/nn400223a
  15. H. S. Yang, W. La, Y. Cho, W. Shin, G. Yeo, B. Kim, “Comparison between heparin-conjugated fibrin and collagen sponge as bone morphogenetic protein-2 carrier for bone regeneration”, Experimental and Molecular Medicine, 2012, 44, 350-355, DOI: 10.3858/emm.2012.44.5.039

B. Refereed Conference Publications

  1. Y. Cho, S. A. Lee, D. N. Oakland, and H. Lu “Microfluidic-based imaging platforms for mechanosensation in C. elegans larvae”, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), Savannah, GA, USA 2017
  2. Y. Cho, D. A. Porto, H. Hwang, L. J. Grundy, W. R. Schafer, and H. Lu “Microfluidics for neuronal functional imaging of multi-modal stimulation.”, C. elegans Neuro meeting
  3. Y. Cho, H. Hwang, D. Porto, and H. Lu, “Microfluidic systems for high-throughput functional imaging of mechanosensing neurons in Caenorhabditis elegans”, the Proceedings of the 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), Gyueongju, Korea, 2015
  4. M. Zhan, Y. Cho, and Hang Lu, “Automatic Long-term microfluidic platform for individual tracking of healthspan and longevity of Caenorhabditis elegans”, the Proceedings of the 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), Gyueongju, Korea, 2015

PRESENTATIONS

A. Invited Talks

  1. “An engineering approach to Systems biology - microfluidics, automation, and machine learning”, Trends in Biological Research, UNIST, South Korea, October 2022, (Online seminar).
  2. “An engineering approach to Systems biology - microfluidics, automation, and machine learning”, Seminar for Energy and Environmental Process, Sogang University, South Korea, December 2020, (Online seminar).

B. Selected Oral Presentations

  1. “Intelligent High-Throughput Intervention Testing Platform in Daphnia” 2022 AIChE, Phoenix AZ, 2022
  2. “Quantitative Strategy for Anti-Aging Drug Discovery using an Intelligent High-Throughput Intervention Testing Platform” 2022 BMES, San Antonio TX, 2022

  3. “Intelligent High-Throughput Intervention Testing Platform in a New Model System” SEED 2022, Arlington VA, August. 2022 (Outstanding Presentation Awards)

  4. “An Intelligent High-Throughput Intervention Testing Platform in Daphnia” 2022 KASBP eSymposium Jun 2022, (Online Symposium)
  5. “Microfluidic-based imaging platforms for mechanosensation in C. elegans larvae”, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, Savannah, GA, 2017.
  6. “Microfluidics for neuronal functional imaging of multi-modal stimulation.”, C. elegans Neuro meeting, Nagoya, Japan, 2016
  7. “Microfluidic Systems for High-Throughput Functional Imaging of Mechanosensing Neurons in C. elegans.”, Neuro Student Seminar, Georgia Tech, Atlanta, 2016
  8. “Microfluidic Systems for High-Throughput Functional Imaging of Mechanosensing Neurons in C. elegans.”, Worm Club, Emory University, Atlanta, 2016
  9. “Microfluidic Systems for High-Throughput Functional Imaging of Mechanosensing Neurons in C. elegans.”, AIChE Annual Meeting, Salt Lake City, 2015.
  10. “Automatic long-term individual tracking microfluidic platform for healthspan and longevity in C. elegans.”, AIChE Annual Meeting, Salt Lake City, 2015.
  11. “Can you use a microfluidic system for long-term observation of behavior?”, International C. elegans meeting, Los Angeles, 2015
  12. “Microfluidic Systems for High-Throughput Functional Imaging of Mechanosensing Neurons in C. elegans.” MicroTAS, South Korea, 2015 (CBMS Student/Young Researcher Grant)
  13. “Automated Microfluidic Platforms for Individually Cultured Nematodes and Neuronal Activity Measurement.” AIChE Annual Meeting, Atlanta, 2014